Seventy-five genetic loci influencing the human red blood cell
Identifieur interne : 005262 ( Main/Exploration ); précédent : 005261; suivant : 005263Seventy-five genetic loci influencing the human red blood cell
Auteurs : Pim Van Der Harst [Pays-Bas] ; Weihua Zhang [Royaume-Uni] ; Irene Mateo Leach [Pays-Bas] ; Augusto Rendon [Royaume-Uni] ; Niek Verweij [Pays-Bas] ; Joban Sehmi [Royaume-Uni] ; Dirk S. Paul [Royaume-Uni] ; Ulrich Elling [Autriche] ; Hooman Allayee [États-Unis] ; Xinzhong Li [Royaume-Uni] ; Aparna Radhakrishnan [Royaume-Uni] ; Sian-Tsung Tan [Royaume-Uni] ; Katrin Voss [Royaume-Uni] ; Christian X. Weichenberger [Italie] ; Cornelis A. Albers [Royaume-Uni] ; Abtehale Al-Hussani [Royaume-Uni] ; Folkert W. Asselbergs [Pays-Bas] ; Marina Ciullo [Italie] ; Fabrice Danjou [Italie] ; Christian Dina [France] ; T Nu Esko [Estonie] ; David M. Evans [Royaume-Uni] ; Lude Franke [Pays-Bas] ; Martin Gögele [Italie] ; Jaana Hartiala [États-Unis] ; Micha Hersch [Suisse] ; Hilma Holm [Islande] ; Jouke-Jan Hottenga [Pays-Bas] ; Stavroula Kanoni [Royaume-Uni] ; Marcus E. Kleber [Allemagne] ; Vasiliki Lagou [Royaume-Uni] ; Claudia Langenberg [Royaume-Uni] ; Lorna M. Lopez [Royaume-Uni] ; Leo-Pekka Lyytik Inen [Finlande] ; Olle Melander [Suède] ; Federico Murgia [Italie] ; Ilja M. Nolte [Pays-Bas] ; Paul F. O Eilly [Royaume-Uni] ; Sandosh Padmanabhan [Royaume-Uni] ; Afshin Parsa [États-Unis] ; Nicola Pirastu [Italie] ; Eleonora Porcu [Italie] ; Laura Portas [Italie] ; Inga Prokopenko [Royaume-Uni] ; Janina S. Ried [Allemagne] ; So-Youn Shin [Royaume-Uni] ; Clara S. Tang [Australie] ; Alexander Teumer [Allemagne] ; Michela Traglia [Italie] ; Sheila Ulivi [Italie] ; Harm-Jan Westra [Pays-Bas] ; Jian Yang [Australie] ; Jing Hua Zhao [Royaume-Uni] ; Franco Anni [Italie] ; Abdel Abdellaoui [Pays-Bas] ; Antony Attwood [Royaume-Uni] ; Beverley Balkau [France] ; Stefania Bandinelli [Italie] ; François Bastardot [Suisse] ; Beben Benyamin [Australie] ; Bernhard O. Boehm [Allemagne] ; William O. Cookson [Royaume-Uni] ; Debashish Das [Royaume-Uni] ; Paul I. W. De Bakker [Pays-Bas, États-Unis] ; Rudolf A. De Boer [Pays-Bas] ; Eco J. C. De Geus [Pays-Bas] ; Marleen H. De Moor [Pays-Bas] ; Maria Dimitriou [Grèce] ; Francisco S. Domingues [Italie] ; Angela Döring [Allemagne] ; Gunnar Engström [Suède] ; Gudmundur Ingi Eyjolfsson [Islande] ; Luigi Ferrucci [États-Unis] ; Krista Fischer [Estonie] ; Renzo Galanello [Italie] ; Stephen F. Garner [Royaume-Uni] ; Bernd Genser [Allemagne] ; Quince D. Gibson [États-Unis, Brésil] ; Giorgia Girotto [Italie] ; Daniel Fannar Gudbjartsson [Islande] ; Sarah E. Harris [Royaume-Uni] ; Anna-Liisa Hartikainen [Finlande] ; Claire E. Hastie [Royaume-Uni] ; Bo Hedblad [Suède] ; Thomas Illig [Allemagne] ; Jennifer Jolley [Royaume-Uni] ; Mika K Hönen [Finlande] ; Ido P. Kema [Pays-Bas] ; John P. Kemp [Royaume-Uni] ; Liming Liang [États-Unis] ; Heather Lloyd-Jones [Royaume-Uni] ; Ruth J. F. Loos [Royaume-Uni] ; Stuart Meacham [Royaume-Uni] ; Sarah E. Medland [Australie] ; Christa Meisinger [Allemagne] ; Yasin Memari [Royaume-Uni] ; Evelin Mihailov [Italie] ; Kathy Miller [Royaume-Uni] ; Miriam F. Moffatt [Royaume-Uni] ; Matthias Nauck [Allemagne] ; Maria Novatchkova [Autriche] ; Teresa Nutile [Italie] ; Isleifur Olafsson [Islande] ; Pall T. Onundarson [Islande] ; Debora Parracciani [Italie] ; Brenda W. Penninx [Pays-Bas] ; Lucia Perseu [Italie] ; Antonio Piga [Italie] ; Giorgio Pistis [Italie] ; Anneli Pouta [Finlande] ; Ursula Puc [Autriche] ; Olli Raitakari [Finlande] ; Susan M. Ring [Royaume-Uni] ; Antonietta Robino [Italie] ; Daniela Ruggiero [Italie] ; Aimo Ruokonen [Finlande] ; Aude Saint-Pierre [Italie] ; Cinzia Sala [Italie] ; Andres Salumets [Estonie] ; Jennifer Sambrook [Royaume-Uni] ; Hein Schepers [Pays-Bas] ; Carsten Oliver Schmidt [Allemagne] ; Herman H. W. Silljé [Pays-Bas] ; Rob Sladek [Canada] ; Johannes H. Smit [Pays-Bas] ; John M. Starr [Royaume-Uni] ; Jonathan Stephens [Royaume-Uni] ; Patrick Sulem [Islande] ; Toshiko Tanaka [États-Unis] ; Unnur Thorsteinsdottir [Islande] ; Vinicius Tragante [Pays-Bas] ; Wiek H. Van Gilst [Pays-Bas] ; L. Joost Van Pelt [Pays-Bas] ; Dirk J. Van Veldhuisen [Pays-Bas] ; Uwe Völker [Allemagne] ; John B. Whitfield [Australie] ; Gonneke Willemsen [Pays-Bas] ; Bernhard R. Winkelmann [Allemagne] ; Gerald Wirnsberger [Autriche] ; Ale Algra [Pays-Bas] ; Francesco Cucca [Italie] ; Adamo Pio D Damo [Italie] ; John Danesh [Royaume-Uni] ; Ian J. Deary [Royaume-Uni] ; Anna F. Dominiczak [Royaume-Uni] ; Paul Elliott [Royaume-Uni] ; Paolo Fortina [États-Unis, Italie] ; Philippe Froguel [France, Royaume-Uni] ; Paolo Gasparini [Italie] ; Andreas Greinacher [Allemagne] ; Stanley L. Hazen [États-Unis] ; Marjo-Riitta Jarvelin [Royaume-Uni, Finlande] ; Kay Tee Khaw [Royaume-Uni] ; Terho Lehtim Ki [Finlande] ; Winfried Maerz [Allemagne] ; Nicholas G. Martin [Australie] ; Andres Metspalu [Estonie] ; Braxton D. Mitchell [États-Unis] ; Grant W. Montgomery [Australie] ; Carmel Moore [Royaume-Uni] ; Gerjan Navis [Pays-Bas] ; Mario Pirastu [Italie] ; Peter P. Pramstaller [Italie, Allemagne] ; Ramiro Ramirez-Solis [Royaume-Uni] ; Eric Schadt [États-Unis] ; James Scott [Royaume-Uni] ; Alan R. Shuldiner [États-Unis] ; George Davey Smith [Royaume-Uni] ; J. Gustav Smith [Suède] ; Harold Snieder [Pays-Bas] ; Rossella Sorice [Italie] ; Tim D. Spector [Royaume-Uni] ; Kari Stefansson [Islande] ; Michael Stumvoll [Allemagne] ; W. H. Wilson Tang [États-Unis] ; Daniela Toniolo [Italie] ; Anke Tönjes [Allemagne] ; Peter M. Visscher [Royaume-Uni, Australie] ; Peter Vollenweider [Suisse] ; Nicholas J. Wareham [Royaume-Uni] ; Bruce H. R. Wolffenbuttel [Pays-Bas] ; Dorret I. Boomsma [Pays-Bas] ; Jacques S. Beckmann [Suisse] ; George V. Dedoussis [Grèce] ; Panos Deloukas [Royaume-Uni] ; Manuel A. Ferreira [Australie] ; Serena Sanna [Italie] ; Manuela Uda [Italie] ; Andrew A. Hicks [Italie] ; Josef Martin Penninger [Autriche] ; Christian Gieger [Allemagne] ; Jaspal S. Kooner [Royaume-Uni] ; Willem H. Ouwehand [Royaume-Uni] ; Nicole Soranzo [Royaume-Uni] ; John C. Chambers [Royaume-Uni]Source :
- Nature [ 0028-0836 ] ; 2012.
Abstract
Anaemia is a chief determinant of globalill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at
Url:
DOI: 10.1038/nature11677
PubMed: 23222517
PubMed Central: 3623669
Affiliations:
- Allemagne, Australie, Autriche, Brésil, Canada, Estonie, Finlande, France, Grèce, Islande, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Attique (région), Bade-Wurtemberg, Basse-Saxe, Canton de Vaud, District de Darmstadt, District de Fribourg-en-Brisgau, District de Karlsruhe, District de Leipzig, District de Tübingen, Finlande occidentale, Grand Londres, Groningue (province), Hauts-de-France, Hesse (Land), Hollande-Méridionale, Latium, Nord-Pas-de-Calais, Oxfordshire, Pays de la Loire, Piémont, Québec, Saxe (Land), Utrecht (province), Vienne (Autriche), Écosse
- Athènes, Cambridge, Francfort-sur-le-Main, Fribourg-en-Brisgau, Glasgow, Groningue (ville), Hanovre, Lausanne, Leipzig, Leyde, Londres, Mannheim, Montréal, Nantes, Oxford, Rome, Turin, Turku, Ulm, Utrecht, Vienne (Autriche), Édimbourg
- University College de Londres, Université Harokopio, Université McGill, Université d'Oxford, Université d'Édimbourg, Université de Cambridge, Université de Glasgow, Université de Groningue, Université de Rome « La Sapienza », Université de Turku
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Le document en format XML
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Hooman" uniqKey="Allayee H" first="Hooman" last="Allayee">Hooman Allayee</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033</wicri:regionArea><wicri:noRegion>California 90033</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><affiliation wicri:level="1"><nlm:aff id="A13">Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Clinical Sciences, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP</wicri:regionArea><wicri:noRegion>London SW3 6NP</wicri:noRegion></affiliation></author><author><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Sian Tsung" sort="Tan, Sian Tsung" uniqKey="Tan S" first="Sian-Tsung" last="Tan">Sian-Tsung Tan</name><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Weichenberger, Christian X" sort="Weichenberger, Christian X" uniqKey="Weichenberger C" first="Christian X." last="Weichenberger">Christian X. Weichenberger</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Albers, Cornelis A" sort="Albers, Cornelis A" uniqKey="Albers C" first="Cornelis A." last="Albers">Cornelis A. Albers</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Al Hussani, Abtehale" sort="Al Hussani, Abtehale" uniqKey="Al Hussani A" first="Abtehale" last="Al-Hussani">Abtehale Al-Hussani</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><affiliation wicri:level="1"><nlm:aff id="A16">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Danjou, Fabrice" sort="Danjou, Fabrice" uniqKey="Danjou F" first="Fabrice" last="Danjou">Fabrice Danjou</name><affiliation wicri:level="1"><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari</wicri:regionArea><wicri:noRegion>09121 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name><affiliation wicri:level="1"><nlm:aff id="A21">Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes</wicri:regionArea><wicri:noRegion>1 Nantes</wicri:noRegion><wicri:noRegion>1 Nantes</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A22">Centre National de la Recherche Scientifique (CNRS) UMR 6291, BP 70721 44007 Nantes cedex 1, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique (CNRS) UMR 6291, BP 70721 44007 Nantes cedex 1, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">School of Medecine, Nantes University, 44000 Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>School of Medecine, Nantes University, 44000 Nantes</wicri:regionArea><wicri:noRegion>44000 Nantes</wicri:noRegion><wicri:noRegion>44000 Nantes</wicri:noRegion></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Hartiala, Jaana" sort="Hartiala, Jaana" uniqKey="Hartiala J" first="Jaana" last="Hartiala">Jaana Hartiala</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033</wicri:regionArea><wicri:noRegion>California 90033</wicri:noRegion></affiliation></author><author><name sortKey="Hersch, Micha" sort="Hersch, Micha" uniqKey="Hersch M" first="Micha" last="Hersch">Micha Hersch</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne</wicri:regionArea><wicri:noRegion>CH-1005 Lausanne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, CH-1015 Lausanne</wicri:regionArea><wicri:noRegion>CH-1015 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation wicri:level="3"><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A32">LURIC Study nonprofit LLC, D-79098 Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>LURIC Study nonprofit LLC, D-79098 Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation wicri:level="1"><nlm:aff id="A33">Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ</wicri:regionArea><wicri:noRegion>University of Oxford OX3 7LJ</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A34">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation wicri:level="1"><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="4"><nlm:aff id="A36">Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, SE-205 02Malmö</wicri:regionArea><wicri:noRegion>SE-205 02Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics, National Research Council of Italy, 07100 Sassari</wicri:regionArea><wicri:noRegion>07100 Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation wicri:level="4"><nlm:aff id="A42">Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F." last="O Eilly">Paul F. O Eilly</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation wicri:level="4"><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation wicri:level="1"><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics, National Research Council of Italy, 07100 Sassari</wicri:regionArea><wicri:noRegion>07100 Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><nlm:aff id="A33">Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ</wicri:regionArea><wicri:noRegion>University of Oxford OX3 7LJ</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A34">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><affiliation wicri:level="1"><nlm:aff id="A47">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Clara S" sort="Tang, Clara S" uniqKey="Tang C" first="Clara S." last="Tang">Clara S. Tang</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="A49">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>D-17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Traglia, Michela" sort="Traglia, Michela" uniqKey="Traglia M" first="Michela" last="Traglia">Michela Traglia</name><affiliation wicri:level="1"><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano</wicri:regionArea><wicri:noRegion>20132 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation wicri:level="1"><nlm:aff id="A52">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102</wicri:regionArea><wicri:noRegion>Queensland 4102</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="1"><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Anni, Franco" sort="Anni, Franco" uniqKey="Anni F" first="Franco" last="Anni">Franco Anni</name><affiliation wicri:level="1"><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari</wicri:regionArea><wicri:noRegion>09121 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Abdellaoui, Abdel" sort="Abdellaoui, Abdel" uniqKey="Abdellaoui A" first="Abdel" last="Abdellaoui">Abdel Abdellaoui</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation wicri:level="3"><nlm:aff id="A53">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A54">University Paris Sud 11, UMRS 1018, Villejuif F-94807, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris Sud 11, UMRS 1018, Villejuif F-94807</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation wicri:level="1"><nlm:aff id="A55">Geriatric Unit, Azienda Sanitaria Firenze, 50125 Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Unit, Azienda Sanitaria Firenze, 50125 Florence</wicri:regionArea><wicri:noRegion>50125 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Bastardot, Francois" sort="Bastardot, Francois" uniqKey="Bastardot F" first="François" last="Bastardot">François Bastardot</name><affiliation wicri:level="1"><nlm:aff id="A56">Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne</wicri:regionArea><wicri:noRegion>CH-1011 Lausanne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne</wicri:regionArea><wicri:noRegion>CH-1011 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072</wicri:regionArea><wicri:noRegion>Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><affiliation wicri:level="3"><nlm:aff id="A59">Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm D-89075, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm D-89075</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Cookson, William O" sort="Cookson, William O" uniqKey="Cookson W" first="William O." last="Cookson">William O. Cookson</name><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Das, Debashish" sort="Das, Debashish" uniqKey="Das D" first="Debashish" last="Das">Debashish Das</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hatter Cardiovascular Institute, University College London, London WC1E 6HX, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Hatter Cardiovascular Institute, University College London, London WC1E 6HX</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation wicri:level="1"><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A62">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea><wicri:noRegion>Massachusetts 02142</wicri:noRegion></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="De Moor, Marleen H" sort="De Moor, Marleen H" uniqKey="De Moor M" first="Marleen H." last="De Moor">Marleen H. De Moor</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation wicri:level="4"><nlm:aff id="A63">Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region><settlement type="city">Athènes</settlement></placeName><orgName type="university">Université Harokopio</orgName></affiliation></author><author><name sortKey="Domingues, Francisco S" sort="Domingues, Francisco S" uniqKey="Domingues F" first="Francisco S." last="Domingues">Francisco S. Domingues</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation wicri:level="1"><nlm:aff id="A64">Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Engstrom, Gunnar" sort="Engstrom, Gunnar" uniqKey="Engstrom G" first="Gunnar" last="Engström">Gunnar Engström</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, SE-205 02Malmö</wicri:regionArea><wicri:noRegion>SE-205 02Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Eyjolfsson, Gudmundur Ingi" sort="Eyjolfsson, Gudmundur Ingi" uniqKey="Eyjolfsson G" first="Gudmundur Ingi" last="Eyjolfsson">Gudmundur Ingi Eyjolfsson</name><affiliation wicri:level="1"><nlm:aff id="A65">The Laboratory in Mjodd, 108 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>The Laboratory in Mjodd, 108 Reykjavik</wicri:regionArea><wicri:noRegion>108 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="A66">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250</wicri:regionArea><wicri:noRegion>Maryland 21250</wicri:noRegion></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Galanello, Renzo" sort="Galanello, Renzo" uniqKey="Galanello R" first="Renzo" last="Galanello">Renzo Galanello</name><affiliation wicri:level="1"><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari</wicri:regionArea><wicri:noRegion>09121 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Garner, Stephen F" sort="Garner, Stephen F" uniqKey="Garner S" first="Stephen F." last="Garner">Stephen F. Garner</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Genser, Bernd" sort="Genser, Bernd" uniqKey="Genser B" first="Bernd" last="Genser">Bernd Genser</name><affiliation wicri:level="3"><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Gibson, Quince D" sort="Gibson, Quince D" uniqKey="Gibson Q" first="Quince D." last="Gibson">Quince D. Gibson</name><affiliation wicri:level="1"><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Bahia 40110-040, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Bahia 40110-040</wicri:regionArea><wicri:noRegion>Bahia 40110-040</wicri:noRegion></affiliation></author><author><name sortKey="Girotto, Giorgia" sort="Girotto, Giorgia" uniqKey="Girotto G" first="Giorgia" last="Girotto">Giorgia Girotto</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Gudbjartsson, Daniel Fannar" sort="Gudbjartsson, Daniel Fannar" uniqKey="Gudbjartsson D" first="Daniel Fannar" last="Gudbjartsson">Daniel Fannar Gudbjartsson</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A68">Medical Genetics Section, The University of Edinburgh, Edinburgh EH4 2XU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Genetics Section, The University of Edinburgh, Edinburgh EH4 2XU</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="A69">Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu FIN-90220 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu FIN-90220 Oulu</wicri:regionArea><wicri:noRegion>University of Oulu FIN-90220 Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Hastie, Claire E" sort="Hastie, Claire E" uniqKey="Hastie C" first="Claire E." last="Hastie">Claire E. Hastie</name><affiliation wicri:level="4"><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, SE-205 02Malmö</wicri:regionArea><wicri:noRegion>SE-205 02Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="1"><nlm:aff id="A70">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A71">Hannover Unified Biobank, Hannover Medical School, D-30625 Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, D-30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="A72">Department of Clinical Physiology, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology, Tampere University Hospital, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A73">Department of Clinical Physiology, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology, University of Tampere School of Medicine, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Kema, Ido P" sort="Kema, Ido P" uniqKey="Kema I" first="Ido P." last="Kema">Ido P. Kema</name><affiliation wicri:level="4"><nlm:aff id="A74">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><affiliation wicri:level="1"><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation wicri:level="1"><nlm:aff id="A75">Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation wicri:level="1"><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation wicri:level="1"><nlm:aff id="A76">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Memari, Yasin" sort="Memari, Yasin" uniqKey="Memari Y" first="Yasin" last="Memari">Yasin Memari</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Kathy" sort="Miller, Kathy" uniqKey="Miller K" first="Kathy" last="Miller">Kathy Miller</name><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation wicri:level="1"><nlm:aff id="A78">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>D-17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Novatchkova, Maria" sort="Novatchkova, Maria" uniqKey="Novatchkova M" first="Maria" last="Novatchkova">Maria Novatchkova</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Nutile, Teresa" sort="Nutile, Teresa" uniqKey="Nutile T" first="Teresa" last="Nutile">Teresa Nutile</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><affiliation wicri:level="1"><nlm:aff id="A79">Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Onundarson, Pall T" sort="Onundarson, Pall T" uniqKey="Onundarson P" first="Pall T." last="Onundarson">Pall T. Onundarson</name><affiliation wicri:level="1"><nlm:aff id="A80">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A81">Laboratory of Hematology and Coagulation Disorder Center, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Laboratory of Hematology and Coagulation Disorder Center, Landspitali University Hospital, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Parracciani, Debora" sort="Parracciani, Debora" uniqKey="Parracciani D" first="Debora" last="Parracciani">Debora Parracciani</name><affiliation wicri:level="1"><nlm:aff id="A82">Genetic Park of Ogliastra, Perdasdefogu, Sardinia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Genetic Park of Ogliastra, Perdasdefogu, Sardinia</wicri:regionArea><wicri:noRegion>Sardinia</wicri:noRegion></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation wicri:level="1"><nlm:aff id="A83">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A84">Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A85">Department of Psychiatry, Leiden University Medical Centre, 2333 Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Centre, 2333 Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Perseu, Lucia" sort="Perseu, Lucia" uniqKey="Perseu L" first="Lucia" last="Perseu">Lucia Perseu</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation></author><author><name sortKey="Piga, Antonio" sort="Piga, Antonio" uniqKey="Piga A" first="Antonio" last="Piga">Antonio Piga</name><affiliation wicri:level="3"><nlm:aff id="A86">Division of Pediatrics and Thalassemia Centre, Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Turin, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Pediatrics and Thalassemia Centre, Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation wicri:level="1"><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano</wicri:regionArea><wicri:noRegion>20132 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="A87">Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, FIN-90220 Oulu</wicri:regionArea><wicri:noRegion>FIN-90220 Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, FIN-90101 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, FIN-90101 Oulu</wicri:regionArea><wicri:noRegion>FIN-90101 Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Puc, Ursula" sort="Puc, Ursula" uniqKey="Puc U" first="Ursula" last="Puc">Ursula Puc</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="A89">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FIN-20521 Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FIN-20521 Turku</wicri:regionArea><wicri:noRegion>FIN-20521 Turku</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A90">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FIN-20521 Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FIN-20521 Turku</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><affiliation wicri:level="1"><nlm:aff id="A91">The School of Social and Community Medicine, University of Bristol, Bristol BS82PS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The School of Social and Community Medicine, University of Bristol, Bristol BS82PS</wicri:regionArea><wicri:noRegion>Bristol BS82PS</wicri:noRegion></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation wicri:level="1"><nlm:aff id="A92">Institute of Diagnostics, University of Oulu, FIN-90014 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Diagnostics, University of Oulu, FIN-90014 Oulu</wicri:regionArea><wicri:noRegion>FIN-90014 Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano</wicri:regionArea><wicri:noRegion>20132 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><affiliation wicri:level="1"><nlm:aff id="A93">Competence Centre on Reproductive Medicine and Biology, 50410 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Competence Centre on Reproductive Medicine and Biology, 50410 Tartu</wicri:regionArea><wicri:noRegion>50410 Tartu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A94">Institute of General and Molecular Pathology, University of Tartu, 51014 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of General and Molecular Pathology, University of Tartu, 51014 Tartu</wicri:regionArea><wicri:noRegion>51014 Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Schepers, Hein" sort="Schepers, Hein" uniqKey="Schepers H" first="Hein" last="Schepers">Hein Schepers</name><affiliation wicri:level="4"><nlm:aff id="A95">Department of Experimental Hematology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Experimental Hematology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A96">Department of Stem Cell Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Stem Cell Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Schmidt, Carsten Oliver" sort="Schmidt, Carsten Oliver" uniqKey="Schmidt C" first="Carsten Oliver" last="Schmidt">Carsten Oliver Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A97">Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>D-17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Sillje, Herman H W" sort="Sillje, Herman H W" uniqKey="Sillje H" first="Herman H. W." last="Silljé">Herman H. W. Silljé</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Sladek, Rob" sort="Sladek, Rob" uniqKey="Sladek R" first="Rob" last="Sladek">Rob Sladek</name><affiliation wicri:level="4"><nlm:aff id="A98">Departments of Human Genetics and Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1B1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Human Genetics and Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1B1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation wicri:level="1"><nlm:aff id="A83">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A99">Geriatric Medicine Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Geriatric Medicine Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation wicri:level="1"><nlm:aff id="A66">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250</wicri:regionArea><wicri:noRegion>Maryland 21250</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A100">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Tragante, Vinicius" sort="Tragante, Vinicius" uniqKey="Tragante V" first="Vinicius" last="Tragante">Vinicius Tragante</name><affiliation wicri:level="1"><nlm:aff id="A16">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><affiliation wicri:level="4"><nlm:aff id="A74">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J." last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:aff id="A49">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>D-17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name><affiliation wicri:level="3"><nlm:aff id="A101">Clin Phenomics Study Center, D-60594 Frankfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clin Phenomics Study Center, D-60594 Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Wirnsberger, Gerald" sort="Wirnsberger, Gerald" uniqKey="Wirnsberger G" first="Gerald" last="Wirnsberger">Gerald Wirnsberger</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name><affiliation wicri:level="1"><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A102">Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht</wicri:regionArea><wicri:noRegion>3584 CG Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A103">Dipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari</wicri:regionArea><wicri:noRegion>07100 Sassari</wicri:noRegion></affiliation></author><author><name sortKey="D Damo, Adamo Pio" sort="D Damo, Adamo Pio" uniqKey="D Damo A" first="Adamo Pio" last="D Damo">Adamo Pio D Damo</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation wicri:level="4"><nlm:aff id="A104">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="4"><nlm:aff id="A36">Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name><affiliation wicri:level="4"><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A105">MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Fortina, Paolo" sort="Fortina, Paolo" uniqKey="Fortina P" first="Paolo" last="Fortina">Paolo Fortina</name><affiliation wicri:level="1"><nlm:aff id="A106">Department of Cancer Biology, Thomas Jefferson University Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Biology, Thomas Jefferson University Jefferson Medical College, Philadelphia, Pennsylvania 19107</wicri:regionArea><wicri:noRegion>Pennsylvania 19107</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A107">Dipartimento di Medicina Molecolare, Università La Sapienza, 00161 Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Molecolare, Università La Sapienza, 00161 Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region><settlement type="city">Rome</settlement></placeName><orgName type="university">Université de Rome « La Sapienza »</orgName></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><nlm:aff id="A108">Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59100, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59100</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A109">Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation wicri:level="1"><nlm:aff id="A110">Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, D-17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>D-17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Hazen, Stanley L" sort="Hazen, Stanley L" uniqKey="Hazen S" first="Stanley L." last="Hazen">Stanley L. Hazen</name><affiliation wicri:level="1"><nlm:aff id="A111">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A87">Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, FIN-90220 Oulu</wicri:regionArea><wicri:noRegion>FIN-90220 Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A105">MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A112">Department of Lifecourse snd Service, National Institute for Health and Welfare, FIN-90101 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Lifecourse snd Service, National Institute for Health and Welfare, FIN-90101 Oulu</wicri:regionArea><wicri:noRegion>FIN-90101 Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A113">Biocenter Oulu, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, FIN-90220 Oulu</wicri:regionArea><wicri:noRegion>FIN-90220 Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A114">Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 2QQ</wicri:noRegion></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name><affiliation wicri:level="3"><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A115">Synlab Academy, D-68165 Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Synlab Academy, D-68165 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Moore, Carmel" sort="Moore, Carmel" uniqKey="Moore C" first="Carmel" last="Moore">Carmel Moore</name><affiliation wicri:level="4"><nlm:aff id="A104">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation wicri:level="4"><nlm:aff id="A116">Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics, National Research Council of Italy, 07100 Sassari</wicri:regionArea><wicri:noRegion>07100 Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A117">Department of Neurology, General Central Hospital, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, General Central Hospital, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A118">Department of Neurology, University of Lübeck, D-23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Lübeck, D-23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>D-23538 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Schadt, Eric" sort="Schadt, Eric" uniqKey="Schadt E" first="Eric" last="Schadt">Eric Schadt</name><affiliation wicri:level="1"><nlm:aff id="A119">Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York 10029-6574, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York 10029-6574</wicri:regionArea><wicri:noRegion>New York 10029-6574</wicri:noRegion></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation wicri:level="1"><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A120">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Smith, J Gustav" sort="Smith, J Gustav" uniqKey="Smith J" first="J. Gustav" last="Smith">J. Gustav Smith</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, SE-205 02Malmö</wicri:regionArea><wicri:noRegion>SE-205 02Malmö</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A121">Department of Cardiology, Lund University, 22185 Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cardiology, Lund University, 22185 Lund</wicri:regionArea><wicri:noRegion>22185 Lund</wicri:noRegion></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="4"><nlm:aff id="A42">Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="A122">Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A100">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation wicri:level="3"><nlm:aff id="A123">Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A124">University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Wilson Tang, W H" sort="Wilson Tang, W H" uniqKey="Wilson Tang W" first="W. H." last="Wilson Tang">W. H. Wilson Tang</name><affiliation wicri:level="1"><nlm:aff id="A111">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation wicri:level="1"><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano</wicri:regionArea><wicri:noRegion>20132 Milano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A125">Insitute of Molecular Genetics, CNR, 27100 Pavia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Insitute of Molecular Genetics, CNR, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation wicri:level="3"><nlm:aff id="A123">Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A124">University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102</wicri:regionArea><wicri:noRegion>Queensland 4102</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072</wicri:regionArea><wicri:noRegion>Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:aff id="A56">Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne</wicri:regionArea><wicri:noRegion>CH-1011 Lausanne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne</wicri:regionArea><wicri:noRegion>CH-1011 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name><affiliation wicri:level="4"><nlm:aff id="A126">Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne</wicri:regionArea><wicri:noRegion>CH-1005 Lausanne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A127">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation wicri:level="4"><nlm:aff id="A63">Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region><settlement type="city">Athènes</settlement></placeName><orgName type="university">Université Harokopio</orgName></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Penninger, Josef Martin" sort="Penninger, Josef Martin" uniqKey="Penninger J" first="Josef Martin" last="Penninger">Josef Martin Penninger</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="A47">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A128">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare NHS Trust, London W12 0HS</wicri:regionArea><wicri:noRegion>London W12 0HS</wicri:noRegion></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP</wicri:regionArea><wicri:noRegion>London SW3 6NP</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A128">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare NHS Trust, London W12 0HS</wicri:regionArea><wicri:noRegion>London W12 0HS</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23222517</idno><idno type="pmc">3623669</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623669</idno><idno type="RBID">PMC:3623669</idno><idno type="doi">10.1038/nature11677</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001D33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D33</idno><idno type="wicri:Area/Pmc/Curation">001B90</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B90</idno><idno type="wicri:Area/Pmc/Checkpoint">001D73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001D73</idno><idno type="wicri:Area/Ncbi/Merge">001058</idno><idno type="wicri:Area/Ncbi/Curation">001058</idno><idno type="wicri:Area/Ncbi/Checkpoint">001058</idno><idno type="wicri:doubleKey">0028-0836:2012:Van Der Harst P:seventy:five:genetic</idno><idno type="wicri:Area/Main/Merge">005466</idno><idno type="wicri:Area/Main/Curation">005262</idno><idno type="wicri:Area/Main/Exploration">005262</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Seventy-five genetic loci influencing the human red blood cell</title><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR</wicri:regionArea><wicri:noRegion>Cambridge CB2 2SR</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Sehmi, Joban" sort="Sehmi, Joban" uniqKey="Sehmi J" first="Joban" last="Sehmi">Joban Sehmi</name><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Paul, Dirk S" sort="Paul, Dirk S" uniqKey="Paul D" first="Dirk S." last="Paul">Dirk S. Paul</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Elling, Ulrich" sort="Elling, Ulrich" uniqKey="Elling U" first="Ulrich" last="Elling">Ulrich Elling</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Allayee, Hooman" sort="Allayee, Hooman" uniqKey="Allayee H" first="Hooman" last="Allayee">Hooman Allayee</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033</wicri:regionArea><wicri:noRegion>California 90033</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><affiliation wicri:level="1"><nlm:aff id="A13">Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Clinical Sciences, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP</wicri:regionArea><wicri:noRegion>London SW3 6NP</wicri:noRegion></affiliation></author><author><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Sian Tsung" sort="Tan, Sian Tsung" uniqKey="Tan S" first="Sian-Tsung" last="Tan">Sian-Tsung Tan</name><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Weichenberger, Christian X" sort="Weichenberger, Christian X" uniqKey="Weichenberger C" first="Christian X." last="Weichenberger">Christian X. Weichenberger</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Albers, Cornelis A" sort="Albers, Cornelis A" uniqKey="Albers C" first="Cornelis A." last="Albers">Cornelis A. Albers</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Al Hussani, Abtehale" sort="Al Hussani, Abtehale" uniqKey="Al Hussani A" first="Abtehale" last="Al-Hussani">Abtehale Al-Hussani</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><affiliation wicri:level="1"><nlm:aff id="A16">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Danjou, Fabrice" sort="Danjou, Fabrice" uniqKey="Danjou F" first="Fabrice" last="Danjou">Fabrice Danjou</name><affiliation wicri:level="1"><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari</wicri:regionArea><wicri:noRegion>09121 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name><affiliation wicri:level="1"><nlm:aff id="A21">Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes</wicri:regionArea><wicri:noRegion>1 Nantes</wicri:noRegion><wicri:noRegion>1 Nantes</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A22">Centre National de la Recherche Scientifique (CNRS) UMR 6291, BP 70721 44007 Nantes cedex 1, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique (CNRS) UMR 6291, BP 70721 44007 Nantes cedex 1, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">School of Medecine, Nantes University, 44000 Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>School of Medecine, Nantes University, 44000 Nantes</wicri:regionArea><wicri:noRegion>44000 Nantes</wicri:noRegion><wicri:noRegion>44000 Nantes</wicri:noRegion></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation wicri:level="1"><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Hartiala, Jaana" sort="Hartiala, Jaana" uniqKey="Hartiala J" first="Jaana" last="Hartiala">Jaana Hartiala</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033</wicri:regionArea><wicri:noRegion>California 90033</wicri:noRegion></affiliation></author><author><name sortKey="Hersch, Micha" sort="Hersch, Micha" uniqKey="Hersch M" first="Micha" last="Hersch">Micha Hersch</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne</wicri:regionArea><wicri:noRegion>CH-1005 Lausanne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, CH-1015 Lausanne</wicri:regionArea><wicri:noRegion>CH-1015 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation wicri:level="3"><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A32">LURIC Study nonprofit LLC, D-79098 Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>LURIC Study nonprofit LLC, D-79098 Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation wicri:level="1"><nlm:aff id="A33">Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ</wicri:regionArea><wicri:noRegion>University of Oxford OX3 7LJ</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A34">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation wicri:level="1"><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation wicri:level="4"><nlm:aff id="A36">Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, SE-205 02Malmö</wicri:regionArea><wicri:noRegion>SE-205 02Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics, National Research Council of Italy, 07100 Sassari</wicri:regionArea><wicri:noRegion>07100 Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation wicri:level="4"><nlm:aff id="A42">Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F." last="O Eilly">Paul F. O Eilly</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation wicri:level="4"><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation wicri:level="1"><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics, National Research Council of Italy, 07100 Sassari</wicri:regionArea><wicri:noRegion>07100 Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><nlm:aff id="A33">Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ</wicri:regionArea><wicri:noRegion>University of Oxford OX3 7LJ</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A34">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><affiliation wicri:level="1"><nlm:aff id="A47">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Clara S" sort="Tang, Clara S" uniqKey="Tang C" first="Clara S." last="Tang">Clara S. Tang</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="A49">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>D-17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Traglia, Michela" sort="Traglia, Michela" uniqKey="Traglia M" first="Michela" last="Traglia">Michela Traglia</name><affiliation wicri:level="1"><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano</wicri:regionArea><wicri:noRegion>20132 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation wicri:level="1"><nlm:aff id="A52">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102</wicri:regionArea><wicri:noRegion>Queensland 4102</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation wicri:level="1"><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Anni, Franco" sort="Anni, Franco" uniqKey="Anni F" first="Franco" last="Anni">Franco Anni</name><affiliation wicri:level="1"><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari</wicri:regionArea><wicri:noRegion>09121 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Abdellaoui, Abdel" sort="Abdellaoui, Abdel" uniqKey="Abdellaoui A" first="Abdel" last="Abdellaoui">Abdel Abdellaoui</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation wicri:level="1"><nlm:aff id="A53">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807</wicri:regionArea><wicri:noRegion>94807</wicri:noRegion><wicri:noRegion>94807</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">University Paris Sud 11, UMRS 1018, Villejuif F-94807, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris Sud 11, UMRS 1018, Villejuif F-94807</wicri:regionArea><wicri:noRegion>94807</wicri:noRegion><wicri:noRegion>94807</wicri:noRegion></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation wicri:level="1"><nlm:aff id="A55">Geriatric Unit, Azienda Sanitaria Firenze, 50125 Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Unit, Azienda Sanitaria Firenze, 50125 Florence</wicri:regionArea><wicri:noRegion>50125 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Bastardot, Francois" sort="Bastardot, Francois" uniqKey="Bastardot F" first="François" last="Bastardot">François Bastardot</name><affiliation wicri:level="1"><nlm:aff id="A56">Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne</wicri:regionArea><wicri:noRegion>CH-1011 Lausanne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne</wicri:regionArea><wicri:noRegion>CH-1011 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072</wicri:regionArea><wicri:noRegion>Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><affiliation wicri:level="3"><nlm:aff id="A59">Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm D-89075, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm D-89075</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Cookson, William O" sort="Cookson, William O" uniqKey="Cookson W" first="William O." last="Cookson">William O. Cookson</name><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Das, Debashish" sort="Das, Debashish" uniqKey="Das D" first="Debashish" last="Das">Debashish Das</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hatter Cardiovascular Institute, University College London, London WC1E 6HX, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Hatter Cardiovascular Institute, University College London, London WC1E 6HX</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation wicri:level="1"><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A62">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea><wicri:noRegion>Massachusetts 02142</wicri:noRegion></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="De Moor, Marleen H" sort="De Moor, Marleen H" uniqKey="De Moor M" first="Marleen H." last="De Moor">Marleen H. De Moor</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation wicri:level="4"><nlm:aff id="A63">Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region><settlement type="city">Athènes</settlement></placeName><orgName type="university">Université Harokopio</orgName></affiliation></author><author><name sortKey="Domingues, Francisco S" sort="Domingues, Francisco S" uniqKey="Domingues F" first="Francisco S." last="Domingues">Francisco S. Domingues</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation wicri:level="1"><nlm:aff id="A64">Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Engstrom, Gunnar" sort="Engstrom, Gunnar" uniqKey="Engstrom G" first="Gunnar" last="Engström">Gunnar Engström</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, SE-205 02Malmö</wicri:regionArea><wicri:noRegion>SE-205 02Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Eyjolfsson, Gudmundur Ingi" sort="Eyjolfsson, Gudmundur Ingi" uniqKey="Eyjolfsson G" first="Gudmundur Ingi" last="Eyjolfsson">Gudmundur Ingi Eyjolfsson</name><affiliation wicri:level="1"><nlm:aff id="A65">The Laboratory in Mjodd, 108 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>The Laboratory in Mjodd, 108 Reykjavik</wicri:regionArea><wicri:noRegion>108 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:aff id="A66">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250</wicri:regionArea><wicri:noRegion>Maryland 21250</wicri:noRegion></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation wicri:level="1"><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Galanello, Renzo" sort="Galanello, Renzo" uniqKey="Galanello R" first="Renzo" last="Galanello">Renzo Galanello</name><affiliation wicri:level="1"><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari</wicri:regionArea><wicri:noRegion>09121 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Garner, Stephen F" sort="Garner, Stephen F" uniqKey="Garner S" first="Stephen F." last="Garner">Stephen F. Garner</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Genser, Bernd" sort="Genser, Bernd" uniqKey="Genser B" first="Bernd" last="Genser">Bernd Genser</name><affiliation wicri:level="3"><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Gibson, Quince D" sort="Gibson, Quince D" uniqKey="Gibson Q" first="Quince D." last="Gibson">Quince D. Gibson</name><affiliation wicri:level="1"><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A67">Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Bahia 40110-040, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Bahia 40110-040</wicri:regionArea><wicri:noRegion>Bahia 40110-040</wicri:noRegion></affiliation></author><author><name sortKey="Girotto, Giorgia" sort="Girotto, Giorgia" uniqKey="Girotto G" first="Giorgia" last="Girotto">Giorgia Girotto</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Gudbjartsson, Daniel Fannar" sort="Gudbjartsson, Daniel Fannar" uniqKey="Gudbjartsson D" first="Daniel Fannar" last="Gudbjartsson">Daniel Fannar Gudbjartsson</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A68">Medical Genetics Section, The University of Edinburgh, Edinburgh EH4 2XU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Genetics Section, The University of Edinburgh, Edinburgh EH4 2XU</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><nlm:aff id="A69">Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu FIN-90220 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu FIN-90220 Oulu</wicri:regionArea><wicri:noRegion>University of Oulu FIN-90220 Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Hastie, Claire E" sort="Hastie, Claire E" uniqKey="Hastie C" first="Claire E." last="Hastie">Claire E. Hastie</name><affiliation wicri:level="4"><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, SE-205 02Malmö</wicri:regionArea><wicri:noRegion>SE-205 02Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="1"><nlm:aff id="A70">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A71">Hannover Unified Biobank, Hannover Medical School, D-30625 Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, D-30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:aff id="A72">Department of Clinical Physiology, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology, Tampere University Hospital, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A73">Department of Clinical Physiology, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology, University of Tampere School of Medicine, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Kema, Ido P" sort="Kema, Ido P" uniqKey="Kema I" first="Ido P." last="Kema">Ido P. Kema</name><affiliation wicri:level="4"><nlm:aff id="A74">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><affiliation wicri:level="1"><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation wicri:level="1"><nlm:aff id="A75">Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation wicri:level="1"><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation wicri:level="1"><nlm:aff id="A76">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Memari, Yasin" sort="Memari, Yasin" uniqKey="Memari Y" first="Yasin" last="Memari">Yasin Memari</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A77">Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Kathy" sort="Miller, Kathy" uniqKey="Miller K" first="Kathy" last="Miller">Kathy Miller</name><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation wicri:level="1"><nlm:aff id="A78">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>D-17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Novatchkova, Maria" sort="Novatchkova, Maria" uniqKey="Novatchkova M" first="Maria" last="Novatchkova">Maria Novatchkova</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Nutile, Teresa" sort="Nutile, Teresa" uniqKey="Nutile T" first="Teresa" last="Nutile">Teresa Nutile</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><affiliation wicri:level="1"><nlm:aff id="A79">Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Onundarson, Pall T" sort="Onundarson, Pall T" uniqKey="Onundarson P" first="Pall T." last="Onundarson">Pall T. Onundarson</name><affiliation wicri:level="1"><nlm:aff id="A80">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A81">Laboratory of Hematology and Coagulation Disorder Center, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Laboratory of Hematology and Coagulation Disorder Center, Landspitali University Hospital, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Parracciani, Debora" sort="Parracciani, Debora" uniqKey="Parracciani D" first="Debora" last="Parracciani">Debora Parracciani</name><affiliation wicri:level="1"><nlm:aff id="A82">Genetic Park of Ogliastra, Perdasdefogu, Sardinia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Genetic Park of Ogliastra, Perdasdefogu, Sardinia</wicri:regionArea><wicri:noRegion>Sardinia</wicri:noRegion></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation wicri:level="1"><nlm:aff id="A83">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A84">Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A85">Department of Psychiatry, Leiden University Medical Centre, 2333 Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Centre, 2333 Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Perseu, Lucia" sort="Perseu, Lucia" uniqKey="Perseu L" first="Lucia" last="Perseu">Lucia Perseu</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation></author><author><name sortKey="Piga, Antonio" sort="Piga, Antonio" uniqKey="Piga A" first="Antonio" last="Piga">Antonio Piga</name><affiliation wicri:level="3"><nlm:aff id="A86">Division of Pediatrics and Thalassemia Centre, Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Turin, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Pediatrics and Thalassemia Centre, Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation wicri:level="1"><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano</wicri:regionArea><wicri:noRegion>20132 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation wicri:level="1"><nlm:aff id="A87">Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, FIN-90220 Oulu</wicri:regionArea><wicri:noRegion>FIN-90220 Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A88">National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, FIN-90101 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, FIN-90101 Oulu</wicri:regionArea><wicri:noRegion>FIN-90101 Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Puc, Ursula" sort="Puc, Ursula" uniqKey="Puc U" first="Ursula" last="Puc">Ursula Puc</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="A89">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FIN-20521 Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FIN-20521 Turku</wicri:regionArea><wicri:noRegion>FIN-20521 Turku</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A90">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FIN-20521 Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FIN-20521 Turku</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><affiliation wicri:level="1"><nlm:aff id="A91">The School of Social and Community Medicine, University of Bristol, Bristol BS82PS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The School of Social and Community Medicine, University of Bristol, Bristol BS82PS</wicri:regionArea><wicri:noRegion>Bristol BS82PS</wicri:noRegion></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation wicri:level="1"><nlm:aff id="A92">Institute of Diagnostics, University of Oulu, FIN-90014 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Diagnostics, University of Oulu, FIN-90014 Oulu</wicri:regionArea><wicri:noRegion>FIN-90014 Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation wicri:level="1"><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano</wicri:regionArea><wicri:noRegion>20132 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><affiliation wicri:level="1"><nlm:aff id="A93">Competence Centre on Reproductive Medicine and Biology, 50410 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Competence Centre on Reproductive Medicine and Biology, 50410 Tartu</wicri:regionArea><wicri:noRegion>50410 Tartu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A94">Institute of General and Molecular Pathology, University of Tartu, 51014 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of General and Molecular Pathology, University of Tartu, 51014 Tartu</wicri:regionArea><wicri:noRegion>51014 Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Schepers, Hein" sort="Schepers, Hein" uniqKey="Schepers H" first="Hein" last="Schepers">Hein Schepers</name><affiliation wicri:level="4"><nlm:aff id="A95">Department of Experimental Hematology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Experimental Hematology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A96">Department of Stem Cell Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Stem Cell Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Schmidt, Carsten Oliver" sort="Schmidt, Carsten Oliver" uniqKey="Schmidt C" first="Carsten Oliver" last="Schmidt">Carsten Oliver Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A97">Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>D-17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Sillje, Herman H W" sort="Sillje, Herman H W" uniqKey="Sillje H" first="Herman H. W." last="Silljé">Herman H. W. Silljé</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Sladek, Rob" sort="Sladek, Rob" uniqKey="Sladek R" first="Rob" last="Sladek">Rob Sladek</name><affiliation wicri:level="4"><nlm:aff id="A98">Departments of Human Genetics and Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1B1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Human Genetics and Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1B1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation wicri:level="1"><nlm:aff id="A83">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A99">Geriatric Medicine Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Geriatric Medicine Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation wicri:level="1"><nlm:aff id="A66">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250</wicri:regionArea><wicri:noRegion>Maryland 21250</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A100">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Tragante, Vinicius" sort="Tragante, Vinicius" uniqKey="Tragante V" first="Vinicius" last="Tragante">Vinicius Tragante</name><affiliation wicri:level="1"><nlm:aff id="A16">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><affiliation wicri:level="4"><nlm:aff id="A74">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J." last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:aff id="A49">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>D-17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name><affiliation wicri:level="3"><nlm:aff id="A101">Clin Phenomics Study Center, D-60594 Frankfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clin Phenomics Study Center, D-60594 Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Wirnsberger, Gerald" sort="Wirnsberger, Gerald" uniqKey="Wirnsberger G" first="Gerald" last="Wirnsberger">Gerald Wirnsberger</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name><affiliation wicri:level="1"><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A102">Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht</wicri:regionArea><wicri:noRegion>3584 CG Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A103">Dipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari</wicri:regionArea><wicri:noRegion>07100 Sassari</wicri:noRegion></affiliation></author><author><name sortKey="D Damo, Adamo Pio" sort="D Damo, Adamo Pio" uniqKey="D Damo A" first="Adamo Pio" last="D Damo">Adamo Pio D Damo</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation wicri:level="4"><nlm:aff id="A104">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation wicri:level="4"><nlm:aff id="A36">Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name><affiliation wicri:level="4"><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A105">MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Fortina, Paolo" sort="Fortina, Paolo" uniqKey="Fortina P" first="Paolo" last="Fortina">Paolo Fortina</name><affiliation wicri:level="1"><nlm:aff id="A106">Department of Cancer Biology, Thomas Jefferson University Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Biology, Thomas Jefferson University Jefferson Medical College, Philadelphia, Pennsylvania 19107</wicri:regionArea><wicri:noRegion>Pennsylvania 19107</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A107">Dipartimento di Medicina Molecolare, Università La Sapienza, 00161 Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Molecolare, Università La Sapienza, 00161 Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region><settlement type="city">Rome</settlement></placeName><orgName type="university">Université de Rome « La Sapienza »</orgName></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><nlm:aff id="A108">Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59100, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59100</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A109">Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation wicri:level="1"><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste</wicri:regionArea><wicri:noRegion>34137 Trieste</wicri:noRegion></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation wicri:level="1"><nlm:aff id="A110">Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, D-17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>D-17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Hazen, Stanley L" sort="Hazen, Stanley L" uniqKey="Hazen S" first="Stanley L." last="Hazen">Stanley L. Hazen</name><affiliation wicri:level="1"><nlm:aff id="A111">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A87">Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Health Sciences, University of Oulu, FIN-90220 Oulu</wicri:regionArea><wicri:noRegion>FIN-90220 Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A105">MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A112">Department of Lifecourse snd Service, National Institute for Health and Welfare, FIN-90101 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Lifecourse snd Service, National Institute for Health and Welfare, FIN-90101 Oulu</wicri:regionArea><wicri:noRegion>FIN-90101 Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A113">Biocenter Oulu, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Biocenter Oulu, University of Oulu, FIN-90220 Oulu</wicri:regionArea><wicri:noRegion>FIN-90220 Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A114">Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 2QQ</wicri:noRegion></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A39">Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere</wicri:regionArea><wicri:noRegion>FIN-33521 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name><affiliation wicri:level="3"><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A115">Synlab Academy, D-68165 Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Synlab Academy, D-68165 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation wicri:level="1"><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center of University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu</wicri:regionArea><wicri:noRegion>51010 Tartu</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Moore, Carmel" sort="Moore, Carmel" uniqKey="Moore C" first="Carmel" last="Moore">Carmel Moore</name><affiliation wicri:level="4"><nlm:aff id="A104">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation wicri:level="4"><nlm:aff id="A116">Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Population Genetics, National Research Council of Italy, 07100 Sassari</wicri:regionArea><wicri:noRegion>07100 Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A117">Department of Neurology, General Central Hospital, 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, General Central Hospital, 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A118">Department of Neurology, University of Lübeck, D-23538 Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Lübeck, D-23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>D-23538 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Schadt, Eric" sort="Schadt, Eric" uniqKey="Schadt E" first="Eric" last="Schadt">Eric Schadt</name><affiliation wicri:level="1"><nlm:aff id="A119">Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York 10029-6574, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York 10029-6574</wicri:regionArea><wicri:noRegion>New York 10029-6574</wicri:noRegion></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation wicri:level="1"><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A120">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN</wicri:regionArea><wicri:noRegion>Bristol BS8 2BN</wicri:noRegion></affiliation></author><author><name sortKey="Smith, J Gustav" sort="Smith, J Gustav" uniqKey="Smith J" first="J. Gustav" last="Smith">J. Gustav Smith</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, SE-205 02Malmö</wicri:regionArea><wicri:noRegion>SE-205 02Malmö</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A121">Department of Cardiology, Lund University, 22185 Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cardiology, Lund University, 22185 Lund</wicri:regionArea><wicri:noRegion>22185 Lund</wicri:noRegion></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="4"><nlm:aff id="A42">Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation wicri:level="1"><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples</wicri:regionArea><wicri:noRegion>80131 Naples</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="A122">Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A100">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation wicri:level="3"><nlm:aff id="A123">Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A124">University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Wilson Tang, W H" sort="Wilson Tang, W H" uniqKey="Wilson Tang W" first="W. H." last="Wilson Tang">W. H. Wilson Tang</name><affiliation wicri:level="1"><nlm:aff id="A111">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation wicri:level="1"><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano</wicri:regionArea><wicri:noRegion>20132 Milano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A125">Insitute of Molecular Genetics, CNR, 27100 Pavia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Insitute of Molecular Genetics, CNR, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation wicri:level="3"><nlm:aff id="A123">Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A124">University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation wicri:level="4"><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A52">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102</wicri:regionArea><wicri:noRegion>Queensland 4102</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072</wicri:regionArea><wicri:noRegion>Queensland 4072</wicri:noRegion></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="1"><nlm:aff id="A56">Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne</wicri:regionArea><wicri:noRegion>CH-1011 Lausanne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne</wicri:regionArea><wicri:noRegion>CH-1011 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="1"><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name><affiliation wicri:level="4"><nlm:aff id="A126">Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biological Psychology, VU University, 1081 BT Amsterdam</wicri:regionArea><wicri:noRegion>1081 BT Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="A27">Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne</wicri:regionArea><wicri:noRegion>CH-1005 Lausanne</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A127">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation wicri:level="4"><nlm:aff id="A63">Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region><settlement type="city">Athènes</settlement></placeName><orgName type="university">Université Harokopio</orgName></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name><affiliation wicri:level="1"><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation wicri:level="1"><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042</wicri:regionArea><wicri:noRegion>Cagliari 09042</wicri:noRegion></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation wicri:level="1"><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano</wicri:regionArea><wicri:noRegion>39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Penninger, Josef Martin" sort="Penninger, Josef Martin" uniqKey="Penninger J" first="Josef Martin" last="Penninger">Josef Martin Penninger</name><affiliation wicri:level="3"><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="A47">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg</wicri:regionArea><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>85764 Neuherberg</wicri:noRegion><wicri:noRegion>D-85764 Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute, Imperial College London, London W12 0NN</wicri:regionArea><wicri:noRegion>London W12 0NN</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A128">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare NHS Trust, London W12 0HS</wicri:regionArea><wicri:noRegion>London W12 0HS</wicri:noRegion></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge, Cambridge CB2 0XY</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, Cambridge CB2 0PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 0PT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ</wicri:regionArea><wicri:noRegion>Cambridge CB2 0QQ</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridge CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG</wicri:regionArea><wicri:noRegion>London W2 1PG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ealing Hospital NHS Trust, Middlesex UB1 3HW</wicri:regionArea><wicri:noRegion>Middlesex UB1 3HW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP</wicri:regionArea><wicri:noRegion>London SW3 6NP</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A128">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare NHS Trust, London W12 0HS</wicri:regionArea><wicri:noRegion>London W12 0HS</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Anaemia is a chief determinant of globalill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at <italic>P</italic> <10<sup>−8</sup>, which together explain 4–9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in <italic>Mus musculus</italic> or <italic>Drosophila melanogaster</italic>. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Brésil</li><li>Canada</li><li>Estonie</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Attique (région)</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Canton de Vaud</li><li>District de Darmstadt</li><li>District de Fribourg-en-Brisgau</li><li>District de Karlsruhe</li><li>District de Leipzig</li><li>District de Tübingen</li><li>Finlande occidentale</li><li>Grand Londres</li><li>Groningue (province)</li><li>Hauts-de-France</li><li>Hesse (Land)</li><li>Hollande-Méridionale</li><li>Latium</li><li>Nord-Pas-de-Calais</li><li>Oxfordshire</li><li>Pays de la Loire</li><li>Piémont</li><li>Québec</li><li>Saxe (Land)</li><li>Utrecht (province)</li><li>Vienne (Autriche)</li><li>Écosse</li></region><settlement><li>Athènes</li><li>Cambridge</li><li>Francfort-sur-le-Main</li><li>Fribourg-en-Brisgau</li><li>Glasgow</li><li>Groningue (ville)</li><li>Hanovre</li><li>Lausanne</li><li>Leipzig</li><li>Leyde</li><li>Londres</li><li>Mannheim</li><li>Montréal</li><li>Nantes</li><li>Oxford</li><li>Rome</li><li>Turin</li><li>Turku</li><li>Ulm</li><li>Utrecht</li><li>Vienne (Autriche)</li><li>Édimbourg</li></settlement><orgName><li>University College de Londres</li><li>Université Harokopio</li><li>Université McGill</li><li>Université d'Oxford</li><li>Université d'Édimbourg</li><li>Université de Cambridge</li><li>Université de Glasgow</li><li>Université de Groningue</li><li>Université de Rome « La Sapienza »</li><li>Université de Turku</li></orgName></list><tree><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name></region><name sortKey="Abdellaoui, Abdel" sort="Abdellaoui, Abdel" uniqKey="Abdellaoui A" first="Abdel" last="Abdellaoui">Abdel Abdellaoui</name><name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name><name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><name sortKey="De Moor, Marleen H" sort="De Moor, Marleen H" uniqKey="De Moor M" first="Marleen H." last="De Moor">Marleen H. De Moor</name><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><name sortKey="Kema, Ido P" sort="Kema, Ido P" uniqKey="Kema I" first="Ido P." last="Kema">Ido P. Kema</name><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><name sortKey="Schepers, Hein" sort="Schepers, Hein" uniqKey="Schepers H" first="Hein" last="Schepers">Hein Schepers</name><name sortKey="Schepers, Hein" sort="Schepers, Hein" uniqKey="Schepers H" first="Hein" last="Schepers">Hein Schepers</name><name sortKey="Sillje, Herman H W" sort="Sillje, Herman H W" uniqKey="Sillje H" first="Herman H. W." last="Silljé">Herman H. W. Silljé</name><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><name sortKey="Tragante, Vinicius" sort="Tragante, Vinicius" uniqKey="Tragante V" first="Vinicius" last="Tragante">Vinicius Tragante</name><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J." last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name></noRegion><name sortKey="Al Hussani, Abtehale" sort="Al Hussani, Abtehale" uniqKey="Al Hussani A" first="Abtehale" last="Al-Hussani">Abtehale Al-Hussani</name><name sortKey="Albers, Cornelis A" sort="Albers, Cornelis A" uniqKey="Albers C" first="Cornelis A." last="Albers">Cornelis A. Albers</name><name sortKey="Albers, Cornelis A" sort="Albers, Cornelis A" uniqKey="Albers C" first="Cornelis A." last="Albers">Cornelis A. Albers</name><name sortKey="Albers, Cornelis A" sort="Albers, Cornelis A" uniqKey="Albers C" first="Cornelis A." last="Albers">Cornelis A. Albers</name><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><name sortKey="Cookson, William O" sort="Cookson, William O" uniqKey="Cookson W" first="William O." last="Cookson">William O. Cookson</name><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><name sortKey="Das, Debashish" sort="Das, Debashish" uniqKey="Das D" first="Debashish" last="Das">Debashish Das</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Garner, Stephen F" sort="Garner, Stephen F" uniqKey="Garner S" first="Stephen F." last="Garner">Stephen F. Garner</name><name sortKey="Garner, Stephen F" sort="Garner, Stephen F" uniqKey="Garner S" first="Stephen F." last="Garner">Stephen F. Garner</name><name sortKey="Garner, Stephen F" sort="Garner, Stephen F" uniqKey="Garner S" first="Stephen F." last="Garner">Stephen F. Garner</name><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><name sortKey="Hastie, Claire E" sort="Hastie, Claire E" uniqKey="Hastie C" first="Claire E." last="Hastie">Claire E. Hastie</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><name sortKey="Memari, Yasin" sort="Memari, Yasin" uniqKey="Memari Y" first="Yasin" last="Memari">Yasin Memari</name><name sortKey="Memari, Yasin" sort="Memari, Yasin" uniqKey="Memari Y" first="Yasin" last="Memari">Yasin Memari</name><name sortKey="Miller, Kathy" sort="Miller, Kathy" uniqKey="Miller K" first="Kathy" last="Miller">Kathy Miller</name><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><name sortKey="Moore, Carmel" sort="Moore, Carmel" uniqKey="Moore C" first="Carmel" last="Moore">Carmel Moore</name><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F." last="O Eilly">Paul F. O Eilly</name><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><name sortKey="Paul, Dirk S" sort="Paul, Dirk S" uniqKey="Paul D" first="Dirk S." last="Paul">Dirk S. Paul</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><name sortKey="Sehmi, Joban" sort="Sehmi, Joban" uniqKey="Sehmi J" first="Joban" last="Sehmi">Joban Sehmi</name><name sortKey="Sehmi, Joban" sort="Sehmi, Joban" uniqKey="Sehmi J" first="Joban" last="Sehmi">Joban Sehmi</name><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><name sortKey="Tan, Sian Tsung" sort="Tan, Sian Tsung" uniqKey="Tan S" first="Sian-Tsung" last="Tan">Sian-Tsung Tan</name><name sortKey="Tan, Sian Tsung" sort="Tan, Sian Tsung" uniqKey="Tan S" first="Sian-Tsung" last="Tan">Sian-Tsung Tan</name><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Elling, Ulrich" sort="Elling, Ulrich" uniqKey="Elling U" first="Ulrich" last="Elling">Ulrich Elling</name></region><name sortKey="Novatchkova, Maria" sort="Novatchkova, Maria" uniqKey="Novatchkova M" first="Maria" last="Novatchkova">Maria Novatchkova</name><name sortKey="Penninger, Josef Martin" sort="Penninger, Josef Martin" uniqKey="Penninger J" first="Josef Martin" last="Penninger">Josef Martin Penninger</name><name sortKey="Puc, Ursula" sort="Puc, Ursula" uniqKey="Puc U" first="Ursula" last="Puc">Ursula Puc</name><name sortKey="Wirnsberger, Gerald" sort="Wirnsberger, Gerald" uniqKey="Wirnsberger G" first="Gerald" last="Wirnsberger">Gerald Wirnsberger</name></country><country name="États-Unis"><noRegion><name sortKey="Allayee, Hooman" sort="Allayee, Hooman" uniqKey="Allayee H" first="Hooman" last="Allayee">Hooman Allayee</name></noRegion><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><name sortKey="Fortina, Paolo" sort="Fortina, Paolo" uniqKey="Fortina P" first="Paolo" last="Fortina">Paolo Fortina</name><name sortKey="Gibson, Quince D" sort="Gibson, Quince D" uniqKey="Gibson Q" first="Quince D." last="Gibson">Quince D. Gibson</name><name sortKey="Hartiala, Jaana" sort="Hartiala, Jaana" uniqKey="Hartiala J" first="Jaana" last="Hartiala">Jaana Hartiala</name><name sortKey="Hazen, Stanley L" sort="Hazen, Stanley L" uniqKey="Hazen S" first="Stanley L." last="Hazen">Stanley L. Hazen</name><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><name sortKey="Schadt, Eric" sort="Schadt, Eric" uniqKey="Schadt E" first="Eric" last="Schadt">Eric Schadt</name><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><name sortKey="Wilson Tang, W H" sort="Wilson Tang, W H" uniqKey="Wilson Tang W" first="W. H." last="Wilson Tang">W. H. Wilson Tang</name></country><country name="Italie"><noRegion><name sortKey="Weichenberger, Christian X" sort="Weichenberger, Christian X" uniqKey="Weichenberger C" first="Christian X." last="Weichenberger">Christian X. Weichenberger</name></noRegion><name sortKey="Anni, Franco" sort="Anni, Franco" uniqKey="Anni F" first="Franco" last="Anni">Franco Anni</name><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><name sortKey="D Damo, Adamo Pio" sort="D Damo, Adamo Pio" uniqKey="D Damo A" first="Adamo Pio" last="D Damo">Adamo Pio D Damo</name><name sortKey="Danjou, Fabrice" sort="Danjou, Fabrice" uniqKey="Danjou F" first="Fabrice" last="Danjou">Fabrice Danjou</name><name sortKey="Domingues, Francisco S" sort="Domingues, Francisco S" uniqKey="Domingues F" first="Francisco S." last="Domingues">Francisco S. Domingues</name><name sortKey="Fortina, Paolo" sort="Fortina, Paolo" uniqKey="Fortina P" first="Paolo" last="Fortina">Paolo Fortina</name><name sortKey="Galanello, Renzo" sort="Galanello, Renzo" uniqKey="Galanello R" first="Renzo" last="Galanello">Renzo Galanello</name><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><name sortKey="Girotto, Giorgia" sort="Girotto, Giorgia" uniqKey="Girotto G" first="Giorgia" last="Girotto">Giorgia Girotto</name><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><name sortKey="Nutile, Teresa" sort="Nutile, Teresa" uniqKey="Nutile T" first="Teresa" last="Nutile">Teresa Nutile</name><name sortKey="Parracciani, Debora" sort="Parracciani, Debora" uniqKey="Parracciani D" first="Debora" last="Parracciani">Debora Parracciani</name><name sortKey="Perseu, Lucia" sort="Perseu, Lucia" uniqKey="Perseu L" first="Lucia" last="Perseu">Lucia Perseu</name><name sortKey="Piga, Antonio" sort="Piga, Antonio" uniqKey="Piga A" first="Antonio" last="Piga">Antonio Piga</name><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><name sortKey="Traglia, Michela" sort="Traglia, Michela" uniqKey="Traglia M" first="Michela" last="Traglia">Michela Traglia</name><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name></country><country name="France"><noRegion><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name></noRegion><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name></country><country name="Estonie"><noRegion><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name></noRegion><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name></country><country name="Suisse"><noRegion><name sortKey="Hersch, Micha" sort="Hersch, Micha" uniqKey="Hersch M" first="Micha" last="Hersch">Micha Hersch</name></noRegion><name sortKey="Bastardot, Francois" sort="Bastardot, Francois" uniqKey="Bastardot F" first="François" last="Bastardot">François Bastardot</name><name sortKey="Bastardot, Francois" sort="Bastardot, Francois" uniqKey="Bastardot F" first="François" last="Bastardot">François Bastardot</name><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><name sortKey="Hersch, Micha" sort="Hersch, Micha" uniqKey="Hersch M" first="Micha" last="Hersch">Micha Hersch</name><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name></country><country name="Islande"><noRegion><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name></noRegion><name sortKey="Eyjolfsson, Gudmundur Ingi" sort="Eyjolfsson, Gudmundur Ingi" uniqKey="Eyjolfsson G" first="Gudmundur Ingi" last="Eyjolfsson">Gudmundur Ingi Eyjolfsson</name><name sortKey="Gudbjartsson, Daniel Fannar" sort="Gudbjartsson, Daniel Fannar" uniqKey="Gudbjartsson D" first="Daniel Fannar" last="Gudbjartsson">Daniel Fannar Gudbjartsson</name><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><name sortKey="Onundarson, Pall T" sort="Onundarson, Pall T" uniqKey="Onundarson P" first="Pall T." last="Onundarson">Pall T. Onundarson</name><name sortKey="Onundarson, Pall T" sort="Onundarson, Pall T" uniqKey="Onundarson P" first="Pall T." last="Onundarson">Pall T. Onundarson</name><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name></region><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><name sortKey="Genser, Bernd" sort="Genser, Bernd" uniqKey="Genser B" first="Bernd" last="Genser">Bernd Genser</name><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. 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Winkelmann</name></country><country name="Finlande"><noRegion><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name></noRegion><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name></country><country name="Suède"><noRegion><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name></noRegion><name sortKey="Engstrom, Gunnar" sort="Engstrom, Gunnar" uniqKey="Engstrom G" first="Gunnar" last="Engström">Gunnar Engström</name><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name><name sortKey="Smith, J Gustav" sort="Smith, J Gustav" uniqKey="Smith J" first="J. Gustav" last="Smith">J. Gustav Smith</name><name sortKey="Smith, J Gustav" sort="Smith, J Gustav" uniqKey="Smith J" first="J. Gustav" last="Smith">J. Gustav Smith</name></country><country name="Australie"><noRegion><name sortKey="Tang, Clara S" sort="Tang, Clara S" uniqKey="Tang C" first="Clara S." last="Tang">Clara S. Tang</name></noRegion><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name></region><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name></country><country name="Brésil"><noRegion><name sortKey="Gibson, Quince D" sort="Gibson, Quince D" uniqKey="Gibson Q" first="Quince D." last="Gibson">Quince D. Gibson</name></noRegion></country><country name="Canada"><region name="Québec"><name sortKey="Sladek, Rob" sort="Sladek, Rob" uniqKey="Sladek R" first="Rob" last="Sladek">Rob Sladek</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Seventy-five genetic loci influencing the human red blood cell
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